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The physiological actions of native GLP-1 are multifaceted and clinically significant

Semaglutide disrupts multiple steps in this chain

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These additions should not alter the semaglutide dose or require titration adjustments

Given the multifactorial nature of SONFH pathogenesis, therapeutic strategies that simultaneously target vascular injury, metabolic dysfunction, and impaired bone remodeling may offer greater efficacy than monotherapies